Blood cell image display apparatus, specimen analyzing system, blood cell image display method and computer program product

ABSTRACT

A blood cell image display apparatus comprising: a classifier for classifying blood cell images, which are obtained by imaging a blood smear prepared from a blood specimen, in accordance with types of blood cells in the blood cell images; an information receiver for receiving information relating to the blood specimen; a display section; and a display controller for determining a type of blood cell as a display object on the basis of the information relating to the blood specimen, and displaying a blood cell image classified as the determined type on the display section, is disclosed. A specimen analyzing system, a blood cell image display method, and a computer program product are also disclosed.

FIELD OF THE INVENTION

The present invention relates to a blood cell image display apparatus, a specimen analyzing system, a blood cell image display method, and a computer program product which is used for the blood cell image display apparatus, the specimen analyzing system or the blood cell image display method.

BACKGROUND

Conventionally, there are known sample imaging apparatuses which image stained blood smears magnified by a microscope and analyze the obtained image to classify blood cells and perform a counting operation.

An automatic blood image analyzing apparatus for automatically classifying white blood cells is described in JP-A-S56-154647. The automatic blood image analyzing apparatus detects a white blood cell by scanning a sample prepared by smearing blood with a microscope for a constant time period, automatically performs a focusing operation after the detection of the white blood cell, converts an image of the white blood cell into an analog electric signal via a television camera and a television camera control unit, obtains various amounts of the characteristics necessary for a characteristic extraction circuit to classify the white blood cell on the basis of a digital image signal of the white blood cell from an A/D converter circuit, and classifies the white blood cell by a microcomputer on the basis of the amounts of the characteristics. If the classification result is an unknown cell or an abnormal white blood cell, the automatic blood image analyzing apparatus stores the digital image signal together with the specimen number of the sample for specifying the image signal and the type of the white blood cell in a cartridge magnetic tape apparatus. When a user wants to perform a sample review after the examination of plural samples, the contents of the cartridge magnetic tape apparatus are read through input from an operator station and a certain white blood cell or an abnormal white blood cell is displayed on an image display apparatus. The displayed certain abnormal white blood cell is then reclassified by human judgment.

There is a disease characterized by the form of a certain type of blood cell, a disease in which a certain type of blood cell is easily misclassified, or the like. For a specimen of a patient having such a disease, it is necessary to mainly re-examine a certain type of blood cell by visual observation carried out by an inspecting engineer or a doctor. However, the automatic blood image analyzing apparatus described in JP-A-S56-154647 is not suitable for such cases.

SUMMARY OF THE INVENTION

The scope of the present invention is defined solely by the appended claims, and is not affected to any degree by the statements within this summary.

A first aspect of the present invention is a blood cell image display apparatus comprising: a classifier for classifying blood cell images, which are obtained by imaging a blood smear prepared from a blood specimen, in accordance with types of blood cells in the blood cell images; an information receiver for receiving information relating to the blood specimen; a display section; and a display controller for determining a type of blood cell as a display object on the basis of the information relating to the blood specimen, and displaying a blood cell image classified as the determined type on the display section.

A second aspect of the present invention is a specimen analyzing system comprising: a blood analyzing apparatus for analyzing blood specimens and outputting analysis results; and a blood cell image display apparatus comprising: an imaging section for imaging a blood smear prepared from a blood specimen and obtaining blood cell images, wherein the blood cell images include blood cells contained in the blood specimen; a classifier for classifying the blood cell images obtained by the imaging section in accordance with types of blood cells in the blood cell images; an analysis result receiver for receiving an analysis result of the blood specimen which has been used for preparing the blood smear; a display section; and a display controller for determining a type of blood cell as a display object on the basis of the analysis result received by the analysis result receiver, and displaying a blood cell image classified as the determined type on the display section.

A third aspect of the present invention is a blood cell image display method comprising: imaging a blood smear prepared from a blood specimen and obtaining blood cell images, wherein the blood cell images include blood cells contained in the blood specimen; classifying the blood cell images in accordance with types of blood cells in the blood cell images; obtaining information relating to the blood specimen; and determining a type of blood cell as a display object on the basis of the obtained information relating to the blood specimen, and displaying the blood cell image classified as the determined type.

A fourth aspect of the present invention is a computer program product comprising: a computer readable medium; and instructions, on the computer readable medium, adapted to enable a general purpose computer to perform operations, comprising: imaging a blood smear prepared from a blood specimen and obtaining blood cell images, wherein the blood cell images include blood cells contained in the blood specimen; classifying the blood cell images in accordance with types of blood cells in the blood cell images; obtaining information relating to the blood specimen; and determining a type of blood cell as a display object on the basis of the obtained information relating to the blood specimen, and displaying the blood cell image classified as the determined type.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a schematic plan view showing the entire configuration of a specimen analyzing system according to an embodiment;

FIG. 2 is a block diagram showing the schematic configuration of a measuring unit provided in a blood cell analyzing apparatus according to the embodiment;

FIG. 3 is a block diagram showing the configuration of an information processing unit provided in the blood cell analyzing apparatus according to the embodiment;

FIG. 4 is a block diagram showing the schematic configuration of a smear preparing apparatus according to the embodiment;

FIG. 5 is a block diagram showing the configuration of a blood cell image display apparatus according to the embodiment;

FIG. 6 is a perspective view showing a portion of the configuration of a microscope unit provided in the blood cell image display apparatus according to the embodiment;

FIG. 7 is a block diagram showing the configuration of an image processing unit provided in the blood cell image display apparatus according to the embodiment;

FIG. 8A is a schematic diagram showing the configuration of a specimen database;

FIG. 8B is a schematic diagram showing the configuration of a blood cell database DB2;

FIG. 9 is a schematic diagram showing the data structure of a review item setting table;

FIG. 10 is a block diagram showing the configuration of a blood cell image display unit provided in the blood cell image display apparatus according to the embodiment;

FIG. 11A is a flowchart showing the procedure of a measuring order obtaining process of a system control apparatus according to the embodiment;

FIG. 11B is a flowchart showing the procedure of a measuring order transmitting process of the system control apparatus according to the embodiment;

FIG. 12 is a flowchart showing the flow of an operation of the information processing unit of the blood cell analyzing apparatus according to the embodiment;

FIG. 13 is a flowchart showing the procedure of an operation of the microscope unit in a blood cell image registration operation;

FIG. 14A is a flowchart (first half) showing the procedure of an operation of the image processing unit in the blood cell image registration operation;

FIG. 14B is a flowchart (second half) showing the procedure of the operation of the image processing unit in the blood cell image registration operation;

FIG. 15 is a diagram explaining a scanning pattern of a specimen on a slide glass in white blood cell detection;

FIG. 16A is a diagram explaining the field of view of a line sensor for white blood cell detection;

FIG. 16B is a diagram showing the signal waveform of the line sensor for white blood cell detection;

FIG. 17A is a flowchart showing the procedure of an initialization operation of the blood cell image display unit in a blood cell image display operation;

FIG. 17B is a flowchart showing the procedure of a specimen information transmitting operation of the image processing unit in the blood cell image display operation;

FIG. 18A is a flowchart showing the procedure of an image display operation of the blood cell image display unit in the blood cell image display operation;

FIG. 18B is a flowchart showing the procedure of a blood cell image transmitting operation of the image processing unit in the blood cell image display operation;

FIG. 18C is a flowchart showing the flow of a re-examination result registration operation of the blood cell image display unit in the blood cell image display operation;

FIG. 19 is a diagram showing an example of a blood cell image review screen;

FIG. 20A is a flowchart showing the flow of a setting screen display operation of the blood cell image display unit in a review item changing operation;

FIG. 20B is a flowchart showing the flow of a review item setting information transmitting operation of the image processing unit in the review item changing operation;

FIG. 20C is a flowchart showing the flow of an operation of accepting a change in review item setting by the blood cell image display unit in the review item changing operation;

FIG. 20D is a flowchart showing the flow of an operation of updating the review item setting table by the image processing unit in the review item changing operation; and

FIG. 21 is a diagram showing an example of a setting screen.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

The preferred embodiments of the present invention will be described hereinafter with reference to the drawings.

This embodiment is a specimen analyzing system which images stained blood smears magnified by a microscope, classifies the blood cell images obtained in this manner, and, in accordance with the specimen, displays a blood cell image requiring re-examination from among the classified blood cell images.

[Configuration of Specimen Analyzing System]

FIG. 1 is a schematic plan view showing the entire configuration of a specimen analyzing system according to this embodiment. As shown in FIG. 1, a specimen analyzing system 1 includes a specimen putting apparatus 2, specimen transport apparatuses 3, a specimen accommodating apparatus 4, blood cell analyzing apparatuses 5, a smear preparing apparatus 6, a blood cell image display apparatus 7 and a system control apparatus 8. The specimen analyzing system 1 according to this embodiment is connected to a host computer 9 via a communication network so as to communicate therewith.

<Configuration of Specimen Putting Apparatus 2>

The specimen putting apparatus 2 includes two specimen delivery units 21 a and 21 b and a bar-code reading unit 22 disposed between the two specimen delivery units 21 a and 21 b. The specimen delivery units 21 a and 21 b of the specimen putting apparatus 2 are configured to place sample racks each storing plural specimen containers. The sample racks placed in the specimen delivery unit 21 a are sequentially delivered to the bar-code reading unit 22. By the bar-code reading unit 22, rack IDs are read from bar-codes of bar-code labels adhered to the sample racks and specimen IDs are read from bar-codes of bar-code labels adhered to the specimen containers, and the rack IDs and the specimen IDs are transmitted to the system control apparatus 8. The sample rack for which the bar-code reading has been completed is transported to the specimen delivery unit 21 b to be transported to the specimen transport apparatus 3 from the specimen delivery unit 21 b.

<Configuration of Specimen Transport Apparatus 3>

Next, the configuration of the specimen transport apparatus 3 will be described. As shown in FIG. 1, the specimen analyzing system 1 includes 4 specimen transport apparatuses 3. The specimen transport apparatuses 3, 3, 3 and 3 are disposed in front of the blood cell analyzing apparatuses 5 and 5, the smear preparing apparatus 6 and the blood cell image display apparatus 7, respectively. The neighboring specimen transport apparatuses 3 and 3 are connected to each other to send and receive a sample rack to each other. The rightmost specimen transport apparatus 3 is connected to the above-described specimen putting apparatus 2 to introduce the sample rack conveyed from the specimen putting apparatus 2 thereto. The leftmost specimen transport apparatus 3 is connected to the specimen accommodating apparatus 4 to convey the sample rack to the specimen accommodating apparatus 4.

Rack sliders 32, 32 and 32 are provided between the specimen putting apparatus 2 and the rightmost specimen transport apparatus 3 (the specimen transport apparatus 3 disposed in front of the blood cell analyzing apparatus 5 on the right side of the drawing) in FIG. 1, between the rightmost specimen transport apparatus 3 described immediately above and the specimen transport apparatus 3 (the specimen transport apparatus 3 disposed in front of the blood cell analyzing apparatus 5 on the left side of the drawing) disposed on the immediate left side of the rightmost specimen transport apparatus, and between the specimen transport apparatus 3 described immediately above and the specimen transport apparatus 3 (the specimen transport apparatus 3 disposed in front of the smear preparing apparatus 6) disposed on the immediate left side of the specimen transport apparatus 3 described immediately above.

The specimen transport apparatus 3 is provided with two rack transport paths 31 a and 31 b extending in a horizontal direction. The rack transport path 31 a at the rear side is a measuring line for transporting a sample rack accommodating a specimen to be supplied to the blood cell analyzing apparatus 5 or the smear preparing apparatus 6. The rack transport path 31 b at the front side is a skip line for transporting a sample rack not accommodating a specimen to be supplied to the blood cell analyzing apparatus 5 or the smear preparing apparatus 6.

The rack slider 32 is disposed on the right side of the specimen transport apparatus 3 to sort and put sample racks into the measuring line 31 a and the skip line 31 b of the specimen transport apparatus 3. The rack slider 32 includes one movable transport path and the movable transport path can be moved in a front-back direction by a motor (not shown).

In addition, the specimen transport apparatus 3 includes a rack bar-code reader and a specimen bar-code reader (not shown) to read a rack ID and a specimen ID by the bar-code readers. Moreover, the specimen transport apparatus 3 is connected to the system control apparatus 8 so as to communicate therewith and is configured to receive a measuring order from the system control apparatus 8. A control section of the specimen transport apparatus 3 determines whether a specimen to be supplied to the blood cell analyzing apparatus 5 or the smear preparing apparatus 6 is accommodated in a sample rack on the basis of the measuring data provided from the system control apparatus 8 and the rack ID read by the bar-code reader.

When a sample rack accommodating the specimen to be supplied to the blood cell analyzing apparatus 5 or the smear preparing apparatus 6 is introduced into the rack slider 32, a movable transport path 32 a is moved to the rear side to deliver the sample rack to the measuring line 31 a. When a sample rack not accommodating the specimen to be supplied to the blood cell analyzing apparatus 5 or the smear preparing apparatus 6 is introduced into the rack slider 32, the movable transport path 32 a is moved to the front side to deliver the sample rack to the skip line 31 b. That is, a sample rack not accommodating a specimen which is an analysis object of the blood cell analyzing apparatus 5 is transported to the skip line 31 b in the specimen transport apparatus 3 disposed in front of the blood cell analyzing apparatus 5, and a sample rack not accommodating a specimen which is a smear preparation object of the smear preparing apparatus 6 is transported to the skip line 31 b in the specimen transport apparatus 3 disposed in front of the smear preparing apparatus 6. When a sample rack accommodates any specimen, which is an analysis object of the blood cell analyzing apparatus 5, the sample rack is transported to the measuring line 31 a in the specimen transport apparatus 3 disposed in front of the blood cell analyzing apparatus 5.

When a sample rack is delivered to the measuring line 31 a, the control section of the specimen transport apparatus 3 repeats an operation of: moving a specimen container which is an object of analysis (smear preparing process) to an aspiration position where the blood cell analyzing apparatus 5 (smear preparing apparatus 6) aspirates a specimen; and moving a specimen container which is the next analysis object (object for smear preparing process) to the aspiration position after the blood cell analyzing apparatus 5 (smear preparing apparatus 6) completes the aspiration of the specimen.

<Configuration of Specimen Accommodating Apparatus 4>

The specimen accommodating apparatus 4 receives the sample rack, in which the analysis or smear preparing is completed, from the specimen transport apparatus 3, and accommodates the sample rack. Since the configuration of the specimen accommodating apparatus is the same as those of the specimen delivery units 21 a and 21 b, a description thereof will be omitted.

<Configuration of Blood Cell Analyzing Apparatus 5>

The blood cell analyzing apparatus 5 as an optical flow cytometry type multiple blood cell analyzing apparatus obtains the fluorescent intensity, the side-scattered light intensity and the like of blood cells included in a blood specimen, classifies the blood cells included in the specimen on the basis of the above intensities, and counts the number of blood cells for each type. Moreover, the blood cell analyzing apparatus 5 creates a scattergram in which the classified blood cells are color-coded for each type, and displays the scattergram. The blood cell analyzing apparatus 5 includes a measuring unit 51 for measuring a blood specimen and an information processing unit 52 for processing measuring data output from the measuring unit 51 and displaying an analysis result of the blood specimen.

FIG. 2 is a block diagram showing the schematic configuration of the measuring unit 51. The measuring unit 51 includes a specimen dispensing section 511, a measuring specimen preparing section 512, an optical detecting section 513, a signal processing circuit 514 and a control section 515.

The specimen dispensing section 511 includes an aspiration tube (not shown) and the aspiration tube is stuck into the cap section of a specimen container in the sample rack transported on the measuring line 31 a of the specimen transport apparatus 3 to aspirate a blood specimen from the specimen container. The measuring specimen preparing section 512 includes a mixing container (not shown) to mix and stir the blood specimen dispensed by the specimen dispensing section 511, a reagent and a diluent and prepare a measuring specimen.

The optical detecting section 513 includes a flow cell (not shown) to form a narrow flow of the measuring specimen by supplying the measuring specimen to the flow cell and exposes the measuring specimen to light to obtain a side-scattered light signal, a forward-scattered light signal and a fluorescent signal by an optical sensor. These signals are output to the signal processing circuit 514. The signal processing circuit 514 processes an electric signal output from the optical detecting section 513. The signal processing circuit 514 obtains parameters such as peaks and pulse widths of the side-scattered light signal, the forward-scattered light signal and the fluorescent signal.

The control section 515 includes a CPU and a memory, and is connected to the specimen transport apparatus 3 so as to perform data communication therewith. The control section 515 controls the specimen dispensing section 511, the measuring specimen preparing section 512, the optical detecting section 513 and the signal processing circuit 514 in accordance with an analysis item provided from the specimen transport apparatus 3, and performs a measurement operation corresponding to the analysis item. In addition, the control section is configured to transmit measuring data including the parameters obtained by the signal processing circuit 514 to the information processing unit 52.

Next, the configuration of the information processing unit 52 will be described. The information processing unit 52 is composed of a computer. FIG. 3 is a block diagram showing the configuration of the information processing unit 52. The information processing unit 52 is realized by a computer 52 a. As shown in FIG. 3, the computer 52 a includes a main body 521, an image display section 522 and an input section 523. The main body 521 includes a CPU 521 a, a ROM 521 b, a RAM 521 c, a hard disk 521 d, a reading device 521 e, an I/O interface 521 f, a communication interface 521 g and an image output interface 521 h. The CPU 521 a, ROM 521 b, RAM 521 c, hard disk 521 d, reading device 521 e, I/O interface 521 f, communication interface 521 g and image output interface 521 h are connected to each other by a bus 521 j.

The CPU 521 a can execute a computer program loaded to the RAM 521 c. The CPU 521 a executes an analysis program 524 a to be described later, so that the computer 52 a functions as the information processing unit 52.

The ROM 521 b is composed of a mask ROM, a PROM, an EPROM, an EEPROM or the like and the computer program which is executed by the CPU 521 a and data which is used for the computer program are recorded in the ROM.

The RAM 521 c is composed of a SRAM, a DRAM or the like. The RAM 521 c is used to read the analysis program 524 a recorded in the hard disk 521 d. Moreover, the RAM is used as an operating area of the CPU 521 a when the CPU 521 a executes a computer program.

In the hard disk 521 d, various computer programs for being executed by the CPU 521 a, such as an operating system and an application program, and data which are used to execute the computer programs are installed. The analysis program 524 a to be described later is also installed in the hard disk 521 d.

The reading device 521 e is composed of a flexible disk drive, a CD-ROM drive, a DVD-ROM drive or the like and can read the computer program or data recorded in a portable recording medium 524. In the portable recording medium 524, the analysis program 524 a for prompting the computer to function as the information processing unit 52 is stored. The computer 52 a can read the analysis program 524 a from the portable recording medium 524 and install the analysis program 524 a in the hard disk 521 d.

The analysis program 524 a is provided by the portable recording medium 524 and can be also provided from an external device, which is connected to the computer 52 a by an electric communication line (which may be wired or wireless) so as to communicate therewith, through the electric communication line. For example, the analysis program 524 a is stored in a hard disk of a server computer on the Internet and the computer 52 a accesses the server computer to download the computer program and install the computer program in the hard disk 521 d.

Furthermore, in the hard disk 521 d, for example, a multitasking operating system such as Windows (registered trade name), which is made and distributed by Microsoft corporation in America, is installed. In the following description, the analysis program 524 a according to this embodiment operates on the above operating system.

The I/O interface 521 f is composed of, for example, a serial interface such as USB, IEEE1394 or RS-232C, a parallel interface such as SCSI, IDE or IEEE1284, and an analog interface including a D/A converter and an A/D converter. The input section 523 composed of a keyboard and a mouse is connected to the I/O interface 521 f and a user uses the input section 523 to input data to the computer 52 a.

The communication interface 521 g is an Ethernet (registered trade name) interface. The communication interface 521 g is connected to the measuring unit 51 via a LAN. Via the communication interface 521 g, the computer 52 a can send and receive data to and from the measuring unit 51 connected to the LAN by using a predetermined communication protocol. In addition, the communication interface 521 g is connected to the host computer 9 via the LAN so as to communicate therewith.

The image output interface 521 h is connected to the image display section 522 composed of a LCD or a CRT to output a picture signal corresponding to the image data provided from the CPU 521 a to the image display section 522. The image display section 522 displays an image (screen) in accordance with an input picture signal.

<Configuration of Smear Preparing Apparatus 6>

The smear preparing apparatus 6 aspirates a blood specimen so as to deliver it onto a slide glass by drops, spreads and dries the blood specimen on the slide glass, and supplies a stain solution to the slide glass to stain the blood on the slide glass. In this manner, the smear preparing apparatus prepares a smear. USP2005-0025672 is hereby incorporated by reference in its entirety as though fully and completely set forth herein.

FIG. 4 is a block diagram showing the schematic configuration of the smear preparing apparatus 6. As shown in FIG. 4, the smear preparing apparatus 6 includes a specimen dispensing section 61, a smearing section 62, a slide glass transport section 63, a staining section 64 and a control section 65.

The specimen dispensing section 61 includes an aspiration tube (not shown) and the aspiration tube is stuck into the cap section of a specimen container in the sample rack transported on the measuring line 31 a of the specimen transport apparatus 3 to aspirate a blood specimen from the specimen container. The specimen dispensing section 61 is configured to drop the aspirated blood specimen onto a slide glass. The smearing section 62 is configured to smear and dry the blood specimen dropped onto the slide glass and perform printing on the slide glass.

The slide glass transport section 63 is provided to accommodate the slide glass on which the blood specimen is smeared by the smearing section 62 in a cassette (not shown) and to transport the cassette. The staining section 64 supplies a stain solution to the slide glass in the cassette transported to a staining position by the slide glass transport section 63. The control section 65 controls the specimen dispensing section 61, the smearing section 62, the slide glass transport section 63 and the staining section 64 in accordance with a smear preparing instruction issued from the specimen transport apparatus 3 so as to perform the above smear preparing operation. The smear prepared in this manner is delivered to the blood cell image display apparatus 7.

<Configuration of Blood Cell Image Display Apparatus 7>

FIG. 5 is a block diagram showing the configuration of the blood cell image display apparatus according to this embodiment. FIG. 5 schematically shows the configuration of the apparatus. The arrangement of sensors, a slide cassette and the like may be slightly different from the actual arrangement to enable an easier understanding. For example, in FIG. 5, a sensor for WBC detection and a sensor for auto-focusing are respectively arranged on the upper and lower sides. However, in fact, as shown in FIG. 6 to be described later, both of the sensors are arranged in substantially the same plane.

A blood cell image display apparatus 7 includes a microscope unit 71 for imaging a magnified image of a blood smear which is focused by auto-focusing, an image processing unit 73 for processing a captured image to classify white blood cells in blood and performing a counting operation for each classification of the white blood cell, and a blood cell image display unit 75 which is connected to the image processing unit 73 and displays the captured image and analysis results. The image processing unit 73 and the blood cell image display unit 75 may be formed integrally, and not separately, with each other. The above-described smear preparing apparatus 6 (for example, a smear preparing apparatus SP-1000i made by Sysmex Corporation) is disposed near the blood cell image display apparatus 7 and a blood smear prepared by the smear preparing apparatus 6 is automatically supplied to the microscope unit 71.

<Configuration of Microscope Unit 71>

FIG. 6 is a perspective view showing a portion of the microscope unit 71. The microscope unit 71 includes an objective lens 712 which is a portion of a lens system of a microscope magnifying the image of blood thinly spread and applied over a slide glass 7 a mounted on an XY stage 711. The XY stage 711 holding a sample (the slide glass 7 a with an upper surface on which the blood is smeared) can be moved back and forth and from side to side (X and Y directions) by a driving section (not shown), the driving of which is controlled by an XY stage driving circuit 713 (see FIG. 5 for reference). The objective lens 712 can be moved up and down (Z direction) by a driving section (not shown), the driving of which is controlled by an objective lens driving circuit 714.

A plurality of the slide glasses 7 a are stacked and accommodated in a slide cassette (not shown). The slide cassette is conveyed from the smear preparing apparatus 6 and received by a receiving section, the driving of which is controlled by a cassette transport driving circuit 716. The XY stage 711 is provided with a chuck section 717 (see FIG. 6 for reference) capable of holding two parts in the vicinities of both ends in the longitudinal direction of the slide glass 7 a, and the chuck section can be freely advanced and retracted with respect to the slide glass 7 a accommodated in the slide cassette 715 which is stopped at a predetermined position. The chuck section 717 is advanced toward the slide cassette 715 to hold the slide glass 7 a by an opening-closing operation of claw sections 717 a which can be freely opened and closed and each of which is formed at the tip of the chuck section 717. Then, the chuck section 717 is retracted to draw the slide glass 7 a from the slide cassette 715 so that the slide glass can be disposed at a predetermined position on the XY stage 711.

A lamp 718 as a light source is disposed below the slide glass 7 a, and light from the lamp 718 passes through the blood on the slide glass 7 a, and via half mirrors 719 and an interference filter 720 arranged on an optical path, enters a line sensor 721 for auto-focusing in which plural pixels are arranged in a line, a sensor 722 for white blood cell (WBC) detection in which plural pixels are arranged in a line and a CCD camera 723. A white blood cell detecting section 724 composed of FPGA, ASIC or the like is connected to the sensor 722 for white blood cell detection and is set up to provide the output signal of the sensor 722 to the white blood cell detecting section 724. A focus calculating section 725 composed of FPGA, ASIC or the like is connected to the sensor 721 for auto-focusing and is set up to provide the output signal of the sensor 721 to the focus calculating section 725. White blood cell detection is performed by the white blood cell detection section 724 on the basis of an output signal in accordance with the incident light of the sensor 722. Information to be used for an auto-focus operation is calculated by the focus calculating section 725 on the basis of an output signal in accordance with the incident light of the sensor 721. The auto-focus operation is performed on the basis of the information.

In addition, the microscope unit 71 includes a control section 726 and communication interfaces 727 and 728. The control section 726 includes a CPU and a memory, and is connected to the XY stage driving circuit 713, the objective lens driving circuit 714, the cassette transport driving circuit 716, the white blood cell detection section 724, the focus calculating section 725 and the communication interfaces 727 and 728 so as to communicate therewith. When the control section 726 executes a control program stored in the memory, the above-described mechanisms are controlled.

The communication interface 727 is an Ethernet (registered trade name) interface. The communication interface 727 is connected to the image processing unit 73 via a communication cable so as to perform data communication therewith. In addition, the communication interface 728 is connected to the CCD camera 723 via an A/D converter 723 a and is connected to the image processing unit 73 via a communication cable. An image signal (analog signal) output from the CCD camera 723 is A/D converted by the A/D converter 723 a and image data (digital data) output from the A/D converter 723 a is provided to the communication interface 728 to be transmitted to the image processing unit 73.

Moreover, the microscope unit 71 includes a two-dimensional bar-code reader 729. A two-dimensional bar-code indicating a specimen ID is printed on a frost section of the slide glass 7 a and the two-dimensional bar-code of the slide glass 7 a introduced into the microscope unit 71 is read by the two-dimensional bar-code reader 729. In this manner, the read specimen ID is provided to the control section 726.

<Configuration of Image Processing Unit 73>

Next, the configuration of the image processing unit 73 will be described. FIG. 7 is a block diagram showing the configuration of the image processing unit 73. The image processing unit 73 is realized by a computer 73 a. As shown in FIG. 7, the computer 73 a includes a main body 731, an image display section 732 and an input section 733. The main body 731 includes a CPU 731 a, a ROM 731 b, a RAM 731 c, a hard disk 731 d, a reading device 731 e, an I/O interface 731 f, a communication interface 731 g and an image output interface 731 j. The CPU 731 a, the ROM 731 b, the RAM 731 c, the hard disk 731 d, the reading device 731 e, the I/O interface 731 f, the communication interface 731 g, a communication interface 731 h, a communication interface 731 i and the image output interface 731 j are connected by a bus 731 k.

The CPU 731 a can execute a computer program loaded to the RAM 731 c. The CPU 731 a executes an image processing program 734 a to be described later, so that the computer 73 a functions as the image processing unit 73.

The ROM 731 b is composed of a mask ROM, a PROM, an EPROM an EEPROM or the like, and the computer program which is executed by the CPU 731 a and data used for the computer program are recorded therein.

The RAM 731 c is composed of a SRAM, a DRAM or the like. The RAM 731 c is used to read the image processing program 734 a recorded in the hard disk 731 d. Moreover, the RAM is used as an operating area of the CPU 731 a when the CPU 731 a executes a computer program.

In the hard disk 731 d, various computer programs for execution by the CPU 731 a, such as an operating system and an application program, and data which are used to execute the computer programs are installed. The image processing program 734 a to be described later is also installed in the hard disk 731 d.

The hard disk 731 d is provided with a blood cell image folder 735 for storing blood cell images. In the blood cell image folder 735, a folder is provided for each specimen and blood cell images obtained as described later are stored in the folder. The folder provided for each specimen has a folder name including a specimen ID, and the corresponding folder can be specified by the specimen ID. The blood cell image folder 735 is set up so as to share data with the blood cell image display unit 75 and the blood cell image display unit 75 can access files stored in the blood cell image folder 735.

Further, the hard disk 731 d is provided with a specimen database DB1 for storing information relating to specimens, and a blood cell database DB2 for storing results of the classification of white blood cells by image processing. FIG. 8A is a schematic diagram showing the configuration of the specimen database DB1 and FIG. 8B is a schematic diagram showing the configuration of the blood cell database DB2. The specimen database DB1 includes a specimen field F11 for storing specimen IDs, fields F12, F13, F14 . . . for storing various information on results that are determined to be abnormal as a result of the analysis of the multiple automatic blood cell analyzing apparatus 5, such as information (white blood cell scattergram abnormality graph) showing whether a white blood cell scattergram abnormality is confirmed, information (NRBC scattergram abnormality graph) showing whether an NRBC (nucleated red blood cell) scattergram abnormality is confirmed and information (neutropenia abnormality graph) showing whether a neutropenia abnormality is confirmed. The specimen database DB1 also includes a field F15 for storing dates of measurements performed by the blood cell image display apparatus 7, a staining abnormality field F16 for storing information (staining abnormality flag) showing whether a staining abnormality has occurred, and a light intensity abnormality field F17 for storing information (lamp light intensity abnormality graph) showing whether a lamp light intensity abnormality has occurred. In the fields storing the information showing abnormalities, such as the white blood cell scattergram abnormality field F12, the NRBC scattergram abnormality field F13, the neutropenia abnormality field F14, the staining abnormality field F16 and the light intensity abnormality field F17, “0” is stored when an abnormality has not occurred, and “1” is stored when an abnormality has occurred. Although omitted for the simplicity of the drawing, the specimen database DB1 is provided with a field for storing the numerical data of the analysis results (the number of white blood cells, the number of red blood cells, et al.) from the blood cell display apparatus 5. Moreover, the specimen database DB1 is also provided with a field for storing patients' names, a field for storing information specifying a hospital ward, a field for storing ages of the patients, a field for storing a number N of white blood cells counted, and the like.

The blood cell database DB2 is provided for each specimen and each blood cell database DB2 includes data indicating a specimen ID. By this, the blood cell database DB2 corresponding to the specimen ID can be specified. The blood cell database DB2 is provided with a white blood cell ID field F21 for storing white blood cell IDs specifying the white blood cells, a type field F22 for storing classification results of the white blood cells and a reconfirmation object field F23 for storing information for specifying the white blood cells which cannot be classified. In the reconfirmation object field F23, “0” stored when the white blood cell classification is normally performed, and “1” is stored when the classification cannot be performed and the white blood cells become an object for reconfirmation.

In addition, in the hard disk 731 d, a review item setting table TBL for setting a blood cell type which becomes a display object when a blood cell image of a specimen is displayed by the blood cell image display unit 75 is provided. FIG. 9 is a diagram schematically showing the data structure of the review item setting table TBL. The review item setting table TBL is data showing the correspondence relationship between the contents of the specimen abnormality which is detected in the analysis of the blood cell analyzing apparatus 5 and a blood cell type (review item) which is an object for the display of the blood cell image display unit 75. That is, a blood cell type to be displayed which corresponds to the specimen abnormality in the analysis result of the blood cell analyzing apparatus 5 is set in accordance with the review item setting table TBL, and thus when a blood cell image is displayed by the blood cell image display unit 75, a blood cell image of the blood cell type corresponding to the abnormality detected in the specimen is displayed. In FIG. 9, blood cell types with a mark ● and a mark * are set as a display object. The mark ● indicates a blood cell type which is set as a display object by the user and the mark * indicates a blood cell type which is fixed as a display object. Regarding the setting of the mark ● and the blank, the user can freely change a display object (mark ●) and a non-display object (blank). On the other hand, regarding the setting of the mark *, the user cannot perform a change into a non-display object. For example, as shown in FIG. 9, for a specimen in which a white blood cell scattergram abnormality appears, all of a banded neutrophil (Band), a segmented neutrophil (Seg), a lymphocyte (Lym), a monocyte (Mono), an eosinophil (Eosin) and a basophil (Baso) are fixed as display objects. On the other hand, for a specimen in which an NRBC scattergram abnormality appears, all of the banded neutrophil, the segmented neutrophil, the lymphocyte, the monocyte, the eosinophil and the basophil are set as non-display objects, but the blood cell types can be changed to be set as display objects.

The reading device 731 e is composed of a flexible disk drive, a CD-ROM drive, a DVD-ROM drive or the like and can read the computer program or data recorded in a portable recording medium 734. In the portable recording medium 734, the image processing program 734 a is stored which prompts the computer to function as the image processing unit 73. The computer 73 a can read the image processing program 734 a from the portable recording medium 734 and install the image processing program 734 a in the hard disk 731 d.

The image processing program 734 a is not only provided by the portable recording medium 734 and can be also provided from an external device, which is connected to the computer 73 a by an electric communication line (which may be wired or wireless) to communicate therewith via the electric communication line. For example, the image processing program 734 a is stored in the hard disk of a server computer on the Internet and the computer 73 a accesses the server computer to download the computer program and install the computer program in the hard disk 731 d.

Furthermore, in the hard disk 731 d, for example, a multitasking operating system is installed such as Windows (registered trade name) which is made and distributed by Microsoft Corporation in America. In the following description, the image processing program 734 a according to this embodiment operates on the above operating system.

The I/O interface 731 f is composed of, for example, a serial interface such as USB, IEEE1394 or RS-232C, a parallel interface such as SCSI, IDE or IEEE1284, and an analog interface including a D/A converter and an A/D converter. The input section 733 is composed of a keyboard and a mouse and is connected to the I/O interface 731 f, and the user uses the input section 733 to input data to the computer 73 a.

The communication interfaces 731 g and 731 h are Ethernet (registered trade name) interfaces. The communication interface 731 g is connected to the blood cell image display unit 75 via a LAN. In addition, the communication interface 731 g is connected to the host computer 9 via the LAN so as to communicate therewith. By using the communication interface 731 g, the computer 73 a can send and receive data between the blood cell image display unit 75 connected to the LAN and the host computer 9 by using a predetermined communication protocol. The communication interface 731 h is connected to the communication interface 727 of the microscope unit 71 via a communication cable so as to perform data communication therewith.

The communication interface 731 i is connected to the communication interface 728 of the microscope unit 71 via a communication cable to perform data communication therewith. Accordingly, images captured by the CCD camera 723 are received by the communication interface 731 i.

The image output interface 731 i is connected to the image display section 732 composed of an LCD or a CRT to output a picture signal corresponding to the image data provided from the CPU 731 a to the image display section 732. The image display section 732 displays an image (screen) in accordance with an input picture signal.

<Configuration of Blood Cell Image Display Unit 75>

The blood cell image display unit 75 is configured from a computer. The blood cell image display unit 75 is connected to the image processing unit 73 via a LAN to read and display blood cell images in the blood cell image folder 735 provided in the hard disk 731 d of the image processing unit 73.

FIG. 10 is a block diagram showing the configuration of a blood cell image display unit 75. The blood cell image display unit 75 is realized by a computer 75 a. As shown in FIG. 10, the computer 75 a includes a main body 751, an image display section 752 and an input section 753. The main body 751 includes a CPU 751 a, a ROM 751 b, a RAM 751 c, a hard disk 751 d, a reading device 751 e, an I/O interface 751 f, a communication interface 751 g and an image output interface 751 h. The CPU 751 a, the ROM 751 b, the RAM 751 c, the hard disk 751 d, the reading device 751 e, the I/O interface 751 f, the communication interface 751 g, and the image output interface 751 h are connected by a bus 751 i.

In the hard disk 751 d, various computer programs for being executed by the CPU 751 a, such as an operating system and an application program, and data which are used to execute the computer programs are installed. A blood cell image display program 754 a to be described later is also installed in the hard disk 751 d.

The reading device 751 e is composed of a flexible disk drive, a CD-ROM drive, a DVD-ROM drive or the like and can read the computer program or data recorded in a portable recording medium 754. In the portable recording medium 754, the blood cell image display program 754 a is stored which prompts the computer to function as the blood cell image display unit 75. The computer 75 a can read the blood cell image display program 754 a from the portable recording medium 754 and install the blood cell image display program 754 a in the hard disk 751 d.

The I/O interface 751 f is composed of, for example, a serial interface such as USB, IEEE1394, SAS, SATA or RS-232C, a parallel interface such as SCSI, IDE or IEEE1284, and an analog interface including a D/A converter and an A/D converter. The input section 753 composed of a keyboard and a mouse is connected to the I/O interface 751 f and the user uses the input section 753 to input data to the computer 75 a.

The communication interface 751 g is an Ethernet (registered trade name) interface. The communication interface 751 g is connected to the image processing unit 73 via a LAN. Via the communication interface 751 g, the computer 75 a can send and receive data between the image processing unit 73 connected to the LAN and a host computer 9 by using a predetermined communication protocol.

Since the other configurations of the blood cell image display unit 75 are the same as the configurations of the above-described image processing unit 73, a description thereof will be omitted.

<Configuration of System Control Apparatus 8>

The system control apparatus 8 is composed of a computer and controls the entire specimen analyzing system 1. The system control apparatus 8 receives a specimen ID and a rack ID from the specimen putting apparatus 2 so as to obtain a measuring order from the host computer 9 using the specimen ID as a key. Moreover, the system control apparatus 8 transmits the measuring order to the specimen transport apparatus 3.

The system control apparatus 8 is realized by a computer 8 a. As shown in FIG. 3, the computer 8 a includes a main body 81, an image display section 82 and an input section 83. The main body 81 includes a CPU 81 a, a ROM 81 b, a RAM 81 c, a hard disk 81 d, a reading device 81 e, an I/O interface 81 f, a communication interface 81 g and an image output interface 81 h. The CPU 81 a, ROM 81 b, RAM 81 c, hard disk 81 d, reading device 81 e, I/O interface 81 f, communication interface 81 g and image output interface 81 h are connected to each other by a bus 81 j.

In the hard disk 81 d, various computer programs for being executed by the CPU 81 a, such as an operating system and an application program, and data which are used to execute the computer programs are installed. A system control program 84 a to be described later is also installed in the hard disk 81 d.

The reading device 81 e is composed of a flexible disk drive, a CD-ROM drive, a DVD-ROM drive or the like and can read the computer program or data recorded in a portable recording medium 84. In the portable recording medium 84, the system control program 84 a for prompting the computer to function as the system control apparatus 8 is stored. The computer 8 a can read the system control program 84 a from the portable recording medium 84 to install the system control program 84 a in the hard disk 81 d.

The I/O interface 81 f is composed of, for example, a serial interface such as USB, IEEE1394 or RS-232C, a parallel interface such as SCSI, IDE or IEEE1284, and an analog interface including a D/A converter and an A/D converter. The input section 83 composed of a keyboard and a mouse is connected to the I/O interface 81 f and the user uses the input section 83 to input data to the computer 8 a.

The communication interface 81 g is an Ethernet (registered trade name) interface. The communication interface 81 g is connected to the specimen putting apparatus 2, the specimen transport apparatus 3, the specimen accommodating apparatus 4 and the host computer 9 via a LAN. Via the communication interface 81 g, the computer 8 a can send and receive data to and from the above respective apparatuses connected to the LAN by using a predetermined communication protocol.

Since the other configurations of the system control apparatus 8 are the same as the configurations of the above-described information processing unit 52, a description thereof will be omitted.

<Configuration of Host Computer 9>

The host computer 9 is composed of a computer and includes a CPU, a ROM, a RAM, a hard disk, a communication interface and the like. The communication interface is connected to the above-described LAN so as to communicate with the system control apparatus 8, the information processing unit 52 of the blood cell analyzing apparatus 5, the image processing unit 73 of the blood cell image display apparatus 7, the specimen putting apparatus 2, the specimen transport apparatus 3 and the specimen accommodating apparatus 4. In the hard disk, measuring orders are stored. When request data for a measuring order including a specimen ID is received from another apparatus, measuring data corresponding to the specimen ID is read from the hard disk and transmitted to the apparatus as a request source. Since the other configurations of the host computer 9 are the same as the configurations of the above-described other computers, a description thereof will be omitted.

Hereinafter, an operation of the specimen analyzing system 1 according to this embodiment will be described.

<Operation of Specimen Putting Apparatus 2>

The user places a sample rack accommodating a specimen container in the specimen delivery unit 21 a and operates an operating panel (not shown) of the specimen delivery unit 21 a to issue an analysis start instruction to the specimen analyzing system 1. A control section of the specimen delivery unit 21 a receives the analysis start instruction and starts the movement of the sample rack in accordance with the instruction. The sample rack placed in the specimen delivery unit 21 a is moved backward on the specimen delivery unit 21 a and is then moved to the left. The sample rack is transferred to the bar-code reading unit 22.

The sample rack introduced into the bar-code reading unit 22 is moved to the left at single pitch intervals on the transport path by a control section of the bar-code reading unit 22. A rack bar-code of the sample rack and a specimen bar-code of the specimen container are read by the bar-code reader and a rack ID and a specimen ID are transmitted to the system control apparatus 8. Next, the sample rack is moved to the left to be delivered to the specimen delivery unit 21 b. A control section of the specimen delivery unit 21 b moves the received sample rack. The sample rack is moved on the specimen delivery unit 21 b and is then moved to the left. The sample rack is transferred to the rack slider 32.

<Measuring Order Obtaining Operation of System Control Apparatus 8>

Next, an operation of the system control apparatus 8 will be described. The system control apparatus obtains a measuring order of a specimen (blood specimen) by the specimen ID received from the specimen putting apparatus 2. Herein, the measuring order is data indicating an instruction of an analysis item to be analyzed for the blood specimen, and includes attribute information of the specimen, such as the specimen ID, patient ID and name of the patient, and information of the analysis item.

FIG. 11A is a flowchart showing the procedure of a process of obtaining a measuring order. A rack ID and specimen IDs transmitted from the specimen putting apparatus 2 are received by the communication interface 81 g of the system control apparatus 8 (Step S101). The system control program 84 a which is executed by the CPU 81 a of the system control apparatus 8 is an event-driven program, and in the CPU 81 a, a process of Step S102 is invoked when an event occurs in which the rack ID and the specimen IDs are received.

In Step S102, the CPU 81 a transmits one of the received specimen IDs and requests a measuring order corresponding to the specimen ID from the host computer 9 (Step S102). The CPU 81 a stands by to receive the measuring order (No in Step S103). When the system control apparatus 8 receives the measuring order transmitted from the host computer 9 (Yes in Step S103), the CPU associates the received measuring order with the rack ID and stores the measuring order in the hard disk 81 d (Step S104). The CPU 81 a determines whether the specimen IDs corresponding to the rack ID, that is, all the specimen IDs of all the specimen containers accommodated in the sample rack having the rack ID have been subjected to an inquiry of measuring order (Step S105). When a specimen ID not subjected to an inquiry of measuring order exists (No in Step S105), the CPU returns the process to Step S102 and requests a measuring order corresponding to the specimen ID not yet subjected to the inquiry of measuring order from the host computer 9.

On the other hand, when all of the specimen IDs have been subjected to the measuring order inquiry (Yes in Step S105), the CPU 81 a completes the process.

<Measuring Order Transmitting Operation of System Control Apparatus 8>

As described later, the specimen transport apparatus 3 transmits a rack ID to the system control apparatus 8 to request a measuring order corresponding to the rack ID. The system control apparatus 8 transmits the measuring order to the specimen transport apparatus 3 in accordance with the request.

FIG. 11B is a flowchart showing the procedure of a measuring order transmitting process. Request data for a measuring order including the rack ID transmitted from the specimen transport apparatus 3 is received by the communication interface 81 g of the system control apparatus 8 (Step S111). In the CPU 81 a, a process of Step S112 is invoked when an event occurs in which the request data of the measuring order is received.

In Step S112, the CPU 81 a searches the measuring order corresponding to the received rack ID from the hard disk 81 d. Next, the CPU 81 a sets a variable i indicating the holding position of the sample rack to 1 (Step S113) and determines whether i is equal to or less than 10 (Step S114). When i is equal to or less than 10 (Yes in Step S114), the CPU 81 a determines whether the specimen container is held at a holding position i (whether there is the measuring order corresponding to the holding position i) (Step S115). When the specimen container is not held at the holding position i (No in Step S115), the CPU 81 a performs a process of Step S117.

When the specimen container is held at the holding position i (Yes in Step S115), the CPU 81 a reads the measuring order of the blood specimen at the holding position i from the hard disk 81 d (Step S116). Then, in Step S117, the CPU 81 a increments i by 1 and returns the process to Step S114. In Step S114, when i is not equal to or less than 10 (No in Step S114), the CPU 81 a transmits the measuring order stored in the RAM 81 c to the specimen transport apparatus 3 as a measuring order request source (Step S118) and completes the process.

<Operation of Specimen Transport Apparatus 3>

Herein, an operation of the specimen transport apparatus 3 disposed in front of the blood cell analyzing apparatus 5 will be described. When a sample rack is transported to the rack slider 32 from the upstream side of transport, a sensor (not shown) detects the arrival of the sample rack. When the arrival of the sample rack is detected, a rack ID is read by the bar-code reader (not shown) from the rack bar-code of the sample rack. The control section of the specimen transport apparatus 3 transmits measuring order request data including the rack ID to the system control apparatus 8. In this manner, a measuring order is transmitted from the system control apparatus 8 as described above and the specimen transport apparatus 3 receives the measuring order. A specimen bar-code reader (not shown) is provided on the measuring line 31 a of the specimen transport apparatus 3 to sequentially read specimen bar-codes of the specimen containers accommodated in the sample rack. The control section of the specimen transport apparatus 3 transmits aspiration instruction data including the measuring order corresponding to the read specimen ID to the blood cell analyzing apparatus 5.

After the aspiration of a specimen by the blood cell analyzing apparatus 5, an aspiration completion notification signal is transmitted from the blood cell analyzing apparatus 5. When the specimen transport apparatus 3 receives the aspiration completion notification signal from the blood cell analyzing apparatus 5, the sample rack is moved by one specimen distance to read the specimen ID of the next specimen container and repeatedly performs the above-described operation. The sample rack in which the aspiration of all the specimens has been completed is transported to the downstream side by the specimen transport apparatus 3.

<Operation of Blood Cell Analyzing Apparatus 5>

Next, an operation of the blood cell analyzing apparatus 5 will be described. FIG. 12 is a flowchart showing the flow of an operation of the information processing unit 52 of the blood cell analyzing apparatus 5. Aspiration instruction data transmitted from the specimen transport apparatus 3 is received by the communication interface 521 g of the information processing unit 52 via the control section 515 of the measuring unit 51 (Step S201). The analysis program 524 a which is executed by the CPU 521 a of the information processing unit 52 is an event-driven program, and in the CPU 521 a, a process of Step S202 is invoked when an event occurs in which the aspiration instruction data is received.

In Step S202, the CPU 521 a transmits order request data including the specimen ID included in the aspiration instruction data to the host computer 9 via the communication interface 521 g (Step S202) to inquire about a measuring order. Then, the CPU 521 a stands by to receive the measuring order (No in Step S203). When the measuring order transmitted from the host computer 9 is received by the communication interface 521 g of the information processing unit 52 (Yes in Step S203), the CPU stores the received measuring order in the hard disk 521 d (Step S204).

Next, the CPU 521 a transmits measurement start request data including the analysis item included in the stored measuring order to the measuring unit 51 (Step S205). The control section 515 of the measuring unit 51 receives the measurement start request data, and thus the blood specimen is measured with respect to the analysis item included in the measurement start request data. After the measurement, the control section 515 of the measuring unit 51 transmits the measuring data (raw data) reflecting the side-scattered light intensity and the fluorescent intensity obtained by the measurement to the information processing unit 52. The CPU 521 a stands by to receive the measuring data (No in Step S206). When the measuring data is received by the communication interface 521 g (Yes in Step S206), the CPU performs a process to analyze the measuring data (Step S207), classifies the blood cells included in the specimen and counts the number of blood cells for each type to create a scattergram in which the classified blood cells are color-coded for each type. In the measuring data analyzing process, abnormalities, such as an abnormality of a white blood cell scattergram (scattergram for classifying white blood cells for each type), an abnormality of an NRBC scattergram (scattergram for detecting a nucleated red blood cell), a neutropenia abnormality indicating that the number of neutrophils falls below a predetermined normal range, a neutrophilia abnormality indicating that the number of neutrophils is more than the normal range, a monocytosis abnormality indicating that the number of monocytes is more than a predetermined normal range, an eosinophilia abnormality indicating that the number of eosinophils is more than a predetermined normal range, a basophilic leukocytosis abnormality indicating that the number of basophils is more than a predetermined normal range, a leucopenia abnormality indicating that the total number of white blood cells falls below a predetermined normal range, a leukocytosis abnormality indicating that the total number of white blood cells is more than a predetermined normal range, and an erythroblastosis abnormality indicating that the number of erythroblasts is more than a predetermined normal range, are detected, and an abnormality flag indicating that an abnormality is detected is added to the analysis result data generated by the analyzing process. The analysis result data generated by the measuring data analyzing process is stored together with the patient information included in the measuring order in the hard disk 521 d (Step S208) and is transmitted to the host computer 9 (Step S209). The host computer 9 integrates the analysis result data and the above-described measuring order and stores the result thereof in the hard disk. After the process of Step S209, the CPU 521 a completes the process.

<Operation of Smear Preparing Apparatus 6>

After receiving the above-described analysis result data, the host computer 9 determines the specimen as an object for smear examination when the analysis result data includes a certain abnormality. In addition, the host computer determines a number N of white blood cells counted in the smear examination in accordance with the type or degree of the abnormality. For the specimen which is determined as an object for smear examination, a new measuring order of the smear examination including the patient information, the analysis result (including the detected abnormality flag) of the blood cell analyzing apparatus 5 and the number N is generated and stored in the hard disk of the host computer 9. After that, when the specimen measuring order is requested by the system control apparatus 8 as described above, the measuring order of the smear examination is transmitted to the system control apparatus 8. Furthermore, in accordance with the inquiry of the specimen transport apparatus 3 which is disposed in front of the smear preparing apparatus 6 as described above, the measuring order is provided to the specimen transport apparatus 3.

In this case, the sample rack is transported on the measuring line 31 a of the specimen transport apparatus 3, and the specimen which is the object for smear examination is aspirated by the smear preparing apparatus 6 by a predetermined amount. Then, the smear preparing apparatus 6 drops the specimen on a slide glass, and thinly spreads and dries the blood specimen on the slide glass. The slide glass is dipped in a stain solution and is then dried. In this manner, a smear is prepared. The smear prepared in this manner is transported to the microscope unit 71 of the blood cell image display apparatus 7.

<Operation of Specimen Accommodating Apparatus 4>

The sample rack delivered from the specimen transport apparatus 3 at the furthest point on the downstream side of the transport is introduced into the specimen accommodating apparatus 4. The specimen accommodating apparatus 4 transports the sample rack on a rack placing section and accommodates the sample rack.

<Operation of Blood Cell Image Display Apparatus 7>

Next, an operation of the blood cell image display apparatus 7 according to this embodiment will be described.

<Blood Cell Image Registration Operation>

First, a blood cell image registration operation of imaging blood cells using the blood cell image display apparatus 7 and storing the blood cell image will be described. FIG. 13 is a flowchart showing the procedure of an operation of the microscope unit 71 in the blood cell image registration operation, and FIGS. 14A and 14B are flowcharts showing the procedure of an operation of the image processing unit 73 in the blood cell image registration operation. When receiving the slide glass 7 a from the blood smear preparing apparatus 6, the microscope unit 71 detects the slide glass via a sensor (not shown) (Step S301). A control program which is executed by the control section 726 is an event-driven program, and in the control section 726 of the microscope unit 71, a process of Step S302 is invoked when an event occurs in which the slide glass 7 a is received from the blood smear preparing apparatus 6.

In Step S302, the control section 726 transports the slide cassette 715 accommodating the received slide glass 7 a to a predetermined bar-code reading position and the specimen bar-code is read by the two-dimensional bar-code reader 729 (Step S302). Next, the control section 726 transmits the specimen ID obtained in Step S302 to the image processing unit 73 via the communication interface 727 (Step S303).

The specimen ID transmitted from the microscope unit 71 is received by the communication interface 731 h of the image processing unit 73 (Step S321 of FIG. 14A). The image processing program 734 a which is executed by the CPU 731 a of the image processing unit 73 is an event-driven program, and in the CPU 731 a, a process of Step S322 is invoked when an event occurs in which the specimen ID is received.

In Step S322, the CPU 731 a transmits order request data including the received specimen ID to the host computer 9 via the communication interface 731 g (Step S322). The order transmitted from the host computer 9 includes the specimen ID, the patient's name, the patient's sex, hospital ward information, comments, analysis results of the multiple automatic blood cell analyzing apparatus (numerical data such as the number of white blood cells and the number of red blood cells, various abnormality information (white blood cell scattergram abnormality flag, NRBC scattergram abnormality flag, neutropenia abnormality flag, neutrophilia abnormality flag, monocytosis abnormality flag, eosinophilia abnormality flag, basophilic leukocytosis abnormality flag, leukopenia abnormality flag, leukocytosis abnormality flag, erythroblastosis abnormality flag, etc.) detected by the blood cell analyzing apparatus 5), and the data of the number N of white blood cells counted. The CPU 731 a stands by to receive the order (No in Step S323). When the measuring order is received (Yes in Step S323), the CPU determines the blood cell type corresponding to the abnormality flag included in the received measuring order as a review item (blood cell type which becomes a display object) in accordance with the review item setting table TBL (Step S324), and stores data indicating the blood cell type determined as the review item in the RAM 731 c.

Next, the CPU 731 a transmits measurement start instruction data including the number N of white blood cells counted, which is included in the measuring order, to the microscope unit 71 by the communication interface 731 h (Step S325), and sets a variable i indicating the number of blood cell images analyzed to 1 (Step S326).

Herein, the microscope unit 71 stands by to receive the measurement start instruction data (No in Step S304 of FIG. 13). When the measurement start instruction data transmitted from the image processing unit 73 is received by the communication interface 727 of the microscope unit 71 (Yes in Step S304), the control section 726 transports the slide cassette 715 to a predetermined position to hold the slide glass 7 a which has been stopped at the predetermined position by the chuck section 717. Then, by retracting the chuck section 717, the slide glass is drawn from the slide cassette 715 and is set at a predetermined position (imaging position) in the XY stage 711 (Step S305). In addition, the control section 726 sets a variable j indicating the number of imaging operations to 1 (Step S306).

Next, the white blood cell in the blood applied to the slide glass 7 a is detected (Step S307). The above detection is performed using the sensor 722. The sensor 722 is a line sensor and has a field of view of about 400 μm. FIG. 15 is a diagram explaining a scanning pattern of the specimen on the slide glass in the white blood cell detection. The control section 726 moves the XY stage 711 in the X and Y directions so that the sensor 722 performs a scan operation on the slide glass 7 a in a substantially zigzag manner from one end toward the other end in the longitudinal direction (see FIG. 15 for reference). Generally, an interval D in the longitudinal direction of the slide glass 7 a of the substantial zigzag scanning is set in the range of about 300 to 500 μm from the viewpoint of preventing detection failures and increasing scanning efficiency. A dimension H in the width direction of the slide glass 7 a being scanned is set in the range of about 14 to 18 mm because the width of the slide glass 7 a is normally about 26 mm.

Red blood cells do not absorb much red color component of light, but the nucleus of a white blood cell does absorb a large amount of the red color component of light. Accordingly, by detecting the red color component, the white blood cells and the red blood cells can be easily distinguished. FIG. 16A is a diagram explaining the field of view of the line sensor 722, and FIG. 16B is a diagram showing a signal waveform of the line sensor 722. FIG. 16A shows that a white blood cell WBC is present in a field of view V of the line sensor 722. In this case, as shown in FIG. 16B, the red color component of a signal detected by the line sensor 722 has a value equal to or less than a reference value S in a part in which the white blood cell WBC is present. Using this phenomenon, the white blood cells can be detected in the blood. By detecting the width W of the portion in which the red color component of the signal has a value equal to or less than the reference value S, it is checked whether the portion emitting the signal is the nucleus of the white blood cell.

Next, the control section 726 performs an auto-focus operation (Step S308). As shown in FIG. 6; the direction of the light passing through the slide glass 7 a and the objective lens 712 is changed by a prism mirror 719 a, and the light is divided into light which is directed to the CCD camera 723 and light which is directed to the sensors 721 and 722 by the half mirrors 719. The line sensor 721 for auto-focusing is composed of two line sensors 721 a and 721 b.

The line sensor 721 a which is one of the two line sensors 721 a and 721 b for auto-focusing is disposed in front of (close to the objective lens on the optical path) a focus position (a position which is in focus), and the other line sensor 721 b is disposed behind (far from the objective lens on the optical path) the focus position. In addition, the position of the objective lens is adjusted on the basis of a value which is obtained by the integral of the difference between the output signals of the two line sensors, so that the focus of the objective lens is on the specimen on the slide glass.

Next, the control section 726 instructs the communication interface 728 to take and transmit the image of the CCD camera 723. Thus, the image of the white blood cell detected in Step S307 is taken (Step S309) and the blood cell image is transmitted to the image processing unit 73 (Step S310). After that, the control section 726 determines whether the required counted number of the white blood cells has been satisfied, that is, whether j is equal to or greater than N (Step S311). When j is less than N (No in Step S311), the control section increments j by 1 (Step S312) and returns the process to Step S307 to repeat the detection of the white blood cells. On the other hand, when j is equal to or greater than N in Step S311 (Yes in Step S311), the control section 726 completes the process.

After the above Step S326, the CPU 731 a stands by to receive the blood cell image (No in Step S327 of FIG. 14A). When the blood cell image transmitted from the microscope unit 71 is received by the communication interface 731 h of the image processing unit 73 (Yes in Step S327), the CPU 731 a performs a correction process on the received blood cell image (Step S328) and stores the blood cell image after the correction in the hard disk 731 d (Step S329). In the process of Step S329, a white blood cell ID corresponding to the blood cell image is generated, and the blood cell image is stored as image data with a file name including the white blood cell ID.

Next, the CPU 731 a specifies areas of cytoplasm and a nucleus in the blood cell image (Step S330). In a stained white blood cell, a nucleus has a color different from that of a cytoplasm. Moreover, the colors of the cytoplasm and the nucleus of the white blood cell are different from the colors of a red blood cell and a background. Accordingly, in the process of Step S330, a nucleus area and a cytoplasm area which are included in a white blood cell image are specified by using a RGB value of the white blood cell image.

Next, the CPU 731 a calculates various characteristic parameters of the white blood cell on the basis of the blood cell image (Step S331). The characteristic parameters include the area of a white blood cell's nucleus, the number of nuclei, irregularity, the tone and concentration (unevenness) of a white blood cell's nucleus, the area, tone and concentration (unevenness) of a white blood cell's cytoplasm, and the area ratio and the concentration ratio between the nucleus and the cytoplasm, which can be obtained on the basis of color signals (G, B, R) of the image.

Next, using the obtained characteristic parameters, the CPU 731 a identifies the type of the white blood cell (Step S332). Specifically, for example, several characteristic parameters of the white blood cell are sequentially compared with judgment criteria values, which are determined for the parameters in advance, to gradually narrow down the type of the white blood cell. In this manner, the imaged white blood cell is classified as a mature white blood cell such as a lymphocyte, a monocyte, an eosinophil, a basophil or a neutrophil (bacillary, lobulated), as an immature white blood cell such as a blast cell, a young granulocyte or an atypical lymphocyte, or as an erythroblast.

Next, in Step S333, the CPU 731 a determines whether the identified blood cell type is included in the review items determined in Step S324 (Step S333). When the blood cell type is included in the review items (Yes in Step S333), the CPU 731 a sets the blood cell image as a display object (Step S334), stores data indicating that the blood cell image is the display object in the RAM 731 c, and performs a process of Step S335. On the other hand, in Step S333, when the blood cell type is not included in the review items (No in Step S333), the CPU 731 a performs the process of Step S335.

In Step S335, the CPU 731 a determines whether the required counted number of the white blood cells has been satisfied, that is, whether i is equal to or greater than N (Step S335). When i is less than N (No in Step S335), the CPU increments i by 1 (Step S336), returns the process to Step S327, and stands by to receive another blood cell image.

On the other hand, when i is equal to or greater than N in Step S335 (Yes in Step S335), the CPU 731 a registers the information relating to the specimen, the classification result and the data indicating the blood cell image as the display object, which are obtained as described above, in the specimen database DB1 and the blood cell database DB2 of the hard disk 731 d (Step S337) and completes the process.

<Operation of Displaying Blood Cell Image>

FIG. 17A is a flowchart showing the procedure of an initialization operation of the blood cell image display unit 75 in a blood cell image display operation, and FIG. 17B is a flowchart showing the procedure of a specimen information transmitting operation of the image processing unit 73 in the blood cell image display operation. The user operates the input section 753 of the computer 75 a to instruct the execution of the blood cell image display program 754 a. The CPU 751 a of the computer 75 a receives the instruction and executes the blood cell image display program 754 a. In this manner, the computer 75 a functions as the blood cell image display unit 75.

Immediately after the initiation of the blood cell image display program 754 a, a login input screen prompting the input of a user's name and a password is displayed (Step S351 of FIG. 17A). The user inputs the user's name and the password in the login input screen (Step S352). The blood cell image display program 754 a, which is executed by the CPU 751 a of the blood cell image display unit 75, is an event-driven program, and in the CPU 751 a, a process of Step S353 is invoked when an event occurs in which the user's name and the password are input.

In Step S353, the CPU 751 a performs a user authentication process. When the user authentication fails (No in Step S354), the CPU 751 a completes the process. When the user is successfully authenticated by using the login process (Yes in Step S354), the CPU 751 a transmits request data of specimen information with the date set as the measurement date to the image processing unit 73 via the communication interface 751 g (Step S355).

The request data transmitted from the blood cell image display unit 75 is received by the communication interface 731 h of the image processing unit 73 (Step S361 of FIG. 17B). In the CPU 731 a, a process of Step S362 is invoked when an event occurs in which the request data is received.

In Step S362, from the specimen database DB1, the CPU 731 a obtains the specimen information with the date set as the measurement date (Step S362). Next, the CPU 731 a transmits the obtained specimen information to the blood cell image display unit 75 via the communication interface 731 g (Step S363) and completes the process.

After transmitting the request data of specimen information, the CPU 751 a of the blood cell image display unit 75 stands by to receive the specimen information (No in Step S356 of FIG. 17A). When the specimen information transmitted from the image processing unit 73 is received by the communication interface 751 g of the blood cell image display unit 75 (Yes in Step S356), a measurement progress screen (not shown) is displayed (Step S357) and the process is completed. In the measurement progress screen, the specimen information relating to plural specimens is displayed as a list. In the measurement progress screen, the user can select one of the pieces of specimen information displayed as a list. By selecting one piece of specimen information and subsequently performing a predetermined operation (for example, the double-clicking of the left button of a mouse), it is possible to provide an instruction for displaying a blood cell image relating to the specimen.

FIG. 18A is a flowchart showing the procedure of an image display operation of the blood cell image display unit 75 in the blood cell image display operation, and FIG. 18B is a flowchart showing the procedure of a blood cell image transmitting operation of the image processing unit 73 in the blood cell image display operation. In the blood cell image display unit 75, when an event occurs, in which the instruction for displaying the blood cell image relating to one specimen is received as described above, in a state in which the measurement progress screen is displayed (Step S371), a process of Step S372 is invoked.

In Step S372, the CPU 751 a transmits blood cell image transmitting request data, including the specimen ID of the specimen for which the instruction is made, to the image processing unit 73 via the communication interface 751 g (Step S372).

The request data transmitted from the blood cell image display unit 75 is received by the communication interface 731 h of the image processing unit 73 (Step S381 of FIG. 18B). In the CPU 731 a, a process of Step S382 is invoked when an event occurs in which the request data is received.

In Step S382, the CPU 731 a obtains classification result information from the blood cell database DB2 corresponding to the specimen ID (Step S382). The classification result information includes white blood cell IDs specifying the white blood cells, the types (monocyte, neutrophil, basophil, eosinophil, lymphocyte, etc.) as the result of the white blood cell classification, information indicating whether the classification can be performed, and information indicating whether the blood cell image is a display object. In addition, in the classification result information, the type information or classification failure information and the display object flag of the white blood cell correspond to the white blood cell ID. That is, from the white blood cell ID, the classification result information can specify the type of the white blood cell or whether the classification of the white blood cell failed, and whether the white blood cell image is a display object.

Next, the CPU 731 a transmits the obtained classification result information to the blood cell image display unit 75 via the communication interface 731 g (Step S383).

After transmitting the request data of the classification result information, the CPU 751 a of the blood cell image display unit 75 stands by to receive the classification result information (No in Step S373 of FIG. 18A). When the classification result information transmitted from the image processing unit 73 is received by the communication interface 751 g of the blood cell image display unit 75 (Yes in Step S373), by the display object flag, a white blood cell ID corresponding to the blood cell image to be displayed is specified from the white blood cell IDs included in the classification result information (Step S374), and the image transmitting request data including the specified white blood cell ID is transmitted to the image processing unit 73 via the communication interface 751 g (Step S375). In Step S374, one or more white blood cell IDs are specified and the image transmitting request data includes all the specified white blood cell IDs.

After transmitting the classification result information, the CPU 731 a of the image processing unit 73 stands by to receive the image transmitting request data (No in Step S384 of FIG. 18B). When the request data transmitted from the blood cell image display unit 75 is received by the communication interface 731 h of the image processing unit 73 (Yes in Step S384), the CPU 731 a reads the blood cell image (after-correction blood cell image) corresponding to the white blood cell ID included in the image transmitting request data from the folder corresponding to the specimen ID in the blood cell image folder 735 in the hard disk 731 d (Step S385), transmits the read blood cell image to the blood cell image display unit 75 via the communication interface 731 g (Step S386), and completes the process.

After transmitting the image transmitting request data, the CPU 751 a of the blood cell image display unit 75 stands by to receive the blood cell image (No in Step S376 of FIG. 18A). When the blood cell image transmitted from the image processing unit 73 is received by the communication interface 751 g of the blood cell image display unit 75 (Yes in Step S376), a blood cell image review screen is displayed (Step S377) and the process is completed.

FIG. 19 is a diagram showing an example of the blood cell image review screen. In a blood cell image review screen W, a blood cell image display area A1 for displaying one or more blood cell images, a patient information display area A2 for displaying patient information, a counted value display area A3 for displaying the result of the counting of each type of classified blood cells, and an analysis result display area A4 for displaying the analysis result of the multiple automatic blood cell analyzing apparatus are included. In the blood cell image display area A1, images which are obtained by reducing received blood cell images are displayed as a list. A blood cell type is displayed with a string of characters (“MONO” for a monocyte, “NEUT” for a neutrophil, “EO” for an eosinophil, “BASO” for a basophil, “LYMP” for a lymphocyte, etc.) in each reduced image. Since the blood cell image display apparatus 7 performs the above-described operation, in the blood cell image review screen W, only the blood cell images of the blood cell types corresponding to the specimen abnormalities detected by the blood cell analyzing apparatus 5 are displayed. This will be described using the example of FIG. 9. In a blood cell image review screen for a specimen having a monocytosis abnormality detected therein, blood cell images of a lymphocyte and a monocyte are displayed. This is because, in the case of the monocytosis abnormality, a monocyte is erroneously identified as a lymphocyte in many cases, and thus an image of the blood cell identified as the lymphocyte is displayed so that the user such as an engineer or a doctor directly confirms the blood cell image by sight and determines whether the monocyte is erroneously identified as the lymphocyte.

In the counted value display area A3 of the blood cell image review screen W, plural buttons, each of which has a character string of a name of a blood cell type displayed therein, are arranged. These buttons can be selected by clicking the left button of a mouse. In a state in which a blood cell image is selected (the blood cell image can also be selected by clicking the left button of the mouse), the user selects a button of a desired blood cell type so that the blood cell image can be classified as the blood cell type.

In the analysis result display area A4 of the blood cell image review screen W, numerical data such as the number of white blood cells and the number of red blood cells and information (in the example of FIG. 19, “neutropenia” is displayed) relating to the specimen abnormality detected by the blood cell analyzing apparatus 5 are displayed as the analysis result of the blood cell analyzing apparatus 5.

FIG. 18C is a flowchart showing the flow of a re-examination result registration operation of the blood cell image display unit 75. As described above, in a state in which the blood cell image review screen is displayed, when input is received to change a blood cell type of a blood cell image (Step S391), the CPU 751 a stores a re-examination result with the changed classification in the RAM 751 c (Step S392). After that, when input is provided to the CPU 751 a by clicking a review completion button provided in the blood cell image review screen to complete the re-examination (Step S393), the CPU 751 a transmits the re-examination result, including the value counted for each blood cell type, which reflects the changed classification result to the image processing unit 73 and the host computer 9 via the communication interface 751 g (Step S394), and completes the process. The re-examination result is received by the image processing unit 73 and the host computer 9 to be registered in the specimen database DB1 and the blood cell database DB2 of the image processing unit 73 and to be stored in the hard disk of the host computer 9.

<Operation of Changing Setting of Review Item>

As described above, the setting of the review item setting table TBL can be changed. FIG. 20A is a flowchart showing the flow of a setting screen display operation of the blood cell image display unit 75 in a review item changing operation, and FIG. 20B is a flowchart showing the flow of a review item setting information transmitting operation of the image processing unit 73 in the review item changing operation. In the blood cell image display unit 75, in a state in which the measurement progress screen is displayed, a setting screen display instruction can be received by clicking a setting button (not shown) disposed in an upper area in the screen with the left button of a mouse. In the CPU 751 a, a process of Step S402 is invoked when an event occurs in which the setting screen display instruction is received (Step S401 of FIG. 20A).

In Step S402, the CPU 751 a transmits review item setting information transmitting request data to the image processing unit 73 via the communication interface 751 g (Step S402).

The request data transmitted from the blood cell image display unit 75 is received by the communication interface 731 h of the image processing unit 73 (Step S411 of FIG. 20B). In the CPU 731 a, a process of Step S412 is invoked when an event occurs in which the request data is received.

In Step S412, the CPU 731 a reads the review item setting table TBL from the hard disk 731 d (Step S412). Next, the CPU 731 a transmits review item setting information indicating the contents of the review item setting table TBL to the blood cell image display unit 75 via the communication interface 731 g (Step S413) and completes the process.

After transmitting the review item setting information request data, the CPU 751 a of the blood cell image display unit 75 stands by to receive the review item setting information (No in Step S403 of FIG. 20A). When the review item setting information transmitted from the image processing unit 73 is received by the communication interface 751 g of the blood cell image display unit 75 (Yes in Step S403), the CPU 751 a displays a setting screen (Step S404) and completes the process.

FIG. 21 is a diagram showing an example of the setting screen. As shown in FIG. 21, a setting screen S is provided with a review item setting information display area A11 in which the setting of the display object/non-display object for each review item is displayed in table format for each abnormality. An abnormality is assigned in each row of the table of the review item setting information display area A11, and a blood cell type as a display object is assigned in each column of the table. That is, each square of the table corresponds to the abnormality of the row to which the square belongs and the blood cell type of the column to which the square belongs. A check mark is displayed in a square set as a display object. For example, a check mark is displayed in the square corresponding to a white blood cell scattergram abnormality and a banded neutrophil, and thus it is shown that the banded neutrophil becomes a display object in the case of the white blood cell scattergram abnormality. In a square, the setting of which can be changed, a rectangular check box CB is displayed. The check box CB can be selected by left-clicking a mouse. When a check box CB in which a check mark is not displayed is selected, the check mark is displayed in this check box CB and a blood cell type corresponding to the check box CB is set as a display object. On the other hand, when a check box CB in which a check mark is displayed is selected, the check mark is removed from this check box CB and a blood cell type corresponding to the check box CB is set as a non-display object. A square, in which a check box CB is not displayed and only a check mark is displayed, is a square which is fixed as a display object. The user can freely set a blood cell type for each specimen abnormality by selecting a check box CB in the review item setting information display area A11 so as to display a blood cell image thereof.

In addition, an OK button B1 and a cancel button B2 are disposed below the review item setting information display area A11 of the setting screen S. The OK button B1 and the cancel button B2 can be selected by clicking the left button of a mouse. When the OK button B1 is selected, the review item setting table TBL is updated with the setting contents displayed in the review item setting information display area A11 and the display of the setting screen S is completed. When the cancel button B2 is selected, the review item setting table TEL is not updated and the display of the setting screen S is completed.

FIG. 20C is a flowchart showing the flow of an operation of accepting a change in review item setting by the blood cell image display unit 75 in the review item changing operation, and FIG. 20D is a flowchart showing the flow of an operation of updating the review item setting table by the image processing unit 73 in the review item changing operation. As described above, when the blood cell image display unit 75 receives input from the user to change the review item setting information (Step S421 of FIG. 20C), the CPU 751 a reflects the contents of the change in the review item setting information of the RAM 751 c (Step S422). Then, when an instruction for updating the review item setting table TBL is received due to the selection of the OK button B1 (Step S423), the CPU 751 a transmits the review item setting information stored in the RAM 751 c to the image processing unit 73 via the communication interface 751 g (Step S424), completes the display of the setting screen S (Step S425), and completes the process.

The review item setting information transmitted from the blood cell image display unit 75 is received by the communication interface 731 h of the image processing unit 73 (Step S431 of FIG. 20D). In the CPU 731 a, a process of Step S432 is invoked when an event occurs in which the review item setting information is received.

In Step S432, the CPU 731 a updates the review item setting table TBL in accordance with the received review item setting information (Step S432) and completes the process. In this manner, the setting of the review item, which has been changed and input by the user, is reflected in the review item setting table TBL.

By employing the above-described configuration, when the blood cell analyzing apparatus 5 analyzes a specimen and a certain abnormality of the blood cell is detected as a result of the analysis, a blood cell image of a blood cell type corresponding to the abnormality is displayed in displaying a blood cell image which is obtained by imaging a blood smear prepared from the specimen for re-examination by an inspecting engineer or a doctor. Accordingly, when an abnormality relating to a disease characterized by the form of a certain type of blood cell, a disease in which a certain type of blood cell is easily misclassified, or the like is detected, the certain blood cell type can be displayed. An inspecting engineer or a doctor visually examines a blood cell image of the certain blood cell type, and in this manner, the re-examination can be achieved with high accuracy.

Further, the setting of a blood cell type as a review item can be changed. Accordingly, in the case in which an abnormality is detected, when a blood cell type attracting attention is changed by a user from a different department, the blood cell type set as a review item can be freely set for each user and convenience of user is improved.

In addition, in some cases, a blood cell type requiring visual examination by an inspecting engineer or a doctor can be specified in accordance with the analysis result of the blood cell analyzing apparatus 5. In the specimen analyzing system 1 according to this embodiment, a blood cell type which becomes a display object is determined in accordance with the analysis result of the blood cell analyzing apparatus 5 and a blood cell image of this blood cell type is displayed. Accordingly, without searching for the blood cell image requiring re-examination, an inspecting engineer or a doctor can confirm the blood cell image of the blood cell type to be confirmed in the re-examination by simply examining the displayed blood cell image visually. In this manner, the re-examination can be easily performed with high accuracy in the specimen analyzing system 1 according to the first embodiment.

Moreover, in many cases, a specimen, in which an abnormality has been detected by the analysis of the blood cell analyzing apparatus 5, requires visual re-examination. Depending on the detected abnormality, a blood cell type attracting attention in the re-examination may be specified. In the specimen analyzing system 1 according to this embodiment, the blood cell type which becomes a display object is determined in accordance with the abnormality detected by the blood cell analyzing apparatus 5 and a blood cell image of the blood cell type requiring visual examination is displayed. Thus, an inspecting engineer or a doctor can easily perform the re-examination with high accuracy by visually examining the displayed blood cell image.

Other Embodiments

In the above-described embodiments, the configuration has been described in which the blood cell image display apparatus 7 automatically obtains the analysis result of the blood cell analyzing apparatus 5 via the host computer 9. However, the invention is not limited to this. A configuration may be employed in which the user inputs the analysis result manually from the input device provided in the blood cell image display apparatus 7. In this case, a configuration may be employed in which only the information necessary for determining the blood cell type which is a display object, that is, in this embodiment, only the information about a specimen abnormality can be input.

In the above-described embodiments, the configuration has been described in which a blood cell type as a display object is determined depending on a specimen abnormality. However, the invention is not limited to this. A configuration may be employed in which a blood cell type as a display object is determined in accordance with the comments added to the analysis result when an inspecting engineer or a doctor confirms the analysis result of the blood cell analyzing apparatus 5. Or, a configuration also may be employed in which a blood cell type as a display object is determined in accordance with a patient's name or a patient's ID. A configuration also may be employed in which a blood cell type as a display object is determined in accordance with the department included in the patient information of the specimen.

In the above-described embodiments, the configuration has been described in which the blood smear prepared by the smear preparing apparatus 6 is automatically delivered to the blood cell image display apparatus 7 from the smear preparing apparatus 6. However, the invention is not limited to this. A configuration may be employed in which the user manually sets a blood smear in the blood cell image display apparatus 7. A configuration also may be employed in which the smear is not automatically prepared by the smear preparing apparatus but is manually prepared by the user of the blood cell image display apparatus 7.

In the above-described embodiments, the configuration has been described in which the user can change the setting of the blood cell type which is a review item. However, the invention is not limited to this. A configuration may be employed in which the blood cell type which is a review item is fixed and cannot be changed.

In the above-described embodiments, the configuration has been described in which, by executing the image processing program, the computer functions as the image processing unit 73 to determine a blood cell image of a display object on the basis of the abnormality information of a specimen. However, the invention is not limited to this. A configuration may also be employed in which the process of determining a blood cell image of a display object is performed using a dedicated hardware such as FPGA, ASIC or the like capable of executing the same process as the image processing program.

In the above-described embodiments, the configuration has been described in which a blood cell image is displayed by the blood cell image display unit 75 which is provided independently of the image processing unit 73. However, the invention is not limited to this. A configuration may be employed in which, by one unit having the function of the image processing unit 73 as well as the function of the blood cell image display unit 75, a blood cell image of a display object is determined on the basis of the abnormality information of a specimen and the determined blood cell image is displayed. Also, a configuration may be employed in which, by one unit having the functions of the microscope unit 71, the image processing unit 73 and the blood cell image display unit 75, the imaging of a slide glass, the reception of the specimen analysis result of the blood cell analyzing apparatus 5, the determination of a blood cell image of a display object on the basis of the abnormality information of the specimen and the display of the blood cell image of the display object are performed.

In the above-described embodiments, the configuration has been described in which all the processes of the image processing program 734 a are executed by the single computer 73 a. However, the invention is not limited to this. A distribution system also can be employed for distributing the same process as the above-described image processing program 734 a to plural apparatuses (computers) and executing the process.

In the above-described embodiments, the configuration has been described in which all the processes of the blood cell image display program 754 a are executed by the single computer 75 a. However, the invention is not limited to this. A distribution system also can be employed for distributing the same process as the above-described blood cell image display program 754 a to plural apparatuses (computers) and executing the process. 

What is claimed is:
 1. A blood cell image display apparatus comprising: a display computer, an image processing computer, and a microscope unit, wherein the image processing computer includes a communication interface configured to communicate with a host computer which is installed outside of the blood cell image display apparatus, wherein the communication interface receives, from the host computer, an order request including a blood specimen analysis result when the analysis result includes detected abnormality information generated by a blood cell analyzing apparatus, and wherein the analysis result is based on raw data representing light intensity, and includes a count of the number of blood cells of each type to create a scattergram; the image processing computer is configured to instruct the microscope unit to image a blood smear prepared from the blood specimen which has been analyzed by the blood cell analyzing apparatus, in accordance with types of blood cells in the blood cell images; the microscope unit is configured to image the blood smear as instructed, and to transmit the blood cell images to the image processing computer; the image processing computer is configured to store the received blood cell images to a storage section, identify the types of blood cells in the stored images, and classify said images according to the identified types of blood cells in the blood cell images; the image processing computer is configured to determine a blood cell image, among the classified blood cell images stored on the storage section, which includes the type of blood cell that corresponds to the received abnormality information in the received analysis result; and the image display computer is configured to display, on a display unit of the image display computer, a blood cell image review screen including the determined blood cell image of the type of blood cell that corresponds to the received abnormality information.
 2. The blood cell image display apparatus according to claim 1, wherein the blood cell image and the order request information are displayed on the display unit.
 3. The blood cell image display apparatus according to claim 1, the microscope unit further comprising: a blood smear receiver for receiving the blood smear prepared from the blood specimen which has been analyzed by the blood cell analyzing apparatus; and an imaging section for imaging the blood smear received by the blood smear receiver to obtain the blood cell image.
 4. The blood cell image display apparatus according to claim 1, wherein the blood cell image display computer is configured to receive an instruction to change the blood cell image displayed on the display unit.
 5. The blood cell image display apparatus according to claim 1, wherein the order request information includes a specimen identification data and a name of a patient.
 6. The blood cell image display apparatus according to claim 1, wherein the abnormality information includes at least one of abnormality information relating to a white blood cell, abnormality information relating to nucleated erythrocyte, abnormality information relating to neutrophil, abnormality information relating to monocyte, abnormality information relating to eosinophil, abnormality information relating to basophil, and abnormality information relating to erythroblast.
 7. A blood cell image display apparatus method comprising: receiving, by a communication interface of an image processing computer of the blood cell image display apparatus, from a host computer which is installed outside of the blood cell image display apparatus, an order request including a blood specimen analysis result when the analysis result includes detected abnormality information generated by a blood cell analyzing apparatus, wherein the analysis result is based on raw data representing light intensity, and includes a count of the number of blood cells of each type to create a scattergram; instructing, by the image processing computer, a microscope unit of the blood cell image display apparatus to image a blood smear prepared from the blood specimen which has been analyzed by the blood cell analyzing apparatus, in accordance with types of blood cells in the blood cell image; imaging, by the microscope unit, the blood smear as instructed; transmitting, by the microscope unit, the blood cell images to the image processing computer; storing, by the image processing computer, the received blood cell images to a storage section; identifying, by the image processing computer, the type of blood cell in the stored images; and classifying, by the image processing computer, the identified blood cell images in accordance with the identified types of blood cells in the blood cell images; determining, by the image processing computer, a blood cell image, among the classified blood cell images stored on the storage section, which includes the type of a blood cell that corresponds to the received abnormality information in the received analysis result; and displaying, by the image display computer on a display unit of the image display computer, a blood cell image review screen including the determined blood cell image of the type of blood cell that corresponds to the received abnormality information.
 8. The blood cell image display apparatus method according to claim 7, further comprising: receiving, by the blood cell image display computer, an instruction to change a type of blood cell displayed on the display unit.
 9. The blood cell image display apparatus method according to claim 7, wherein the abnormality information includes at least one of abnormality information relating to a white blood cell, abnormality information relating to nucleated erythrocyte, abnormality information relating to neutrophil, abnormality information relating to monocyte, abnormality information relating to eosinophil, abnormality information relating to basophil, and abnormality information relating to erythroblast.
 10. The blood cell image display apparatus method according to claim 7, wherein the order request information includes a specimen identification data and a name of a patient.
 11. The blood cell image display apparatus method according to claim 7, wherein the blood cell image and the order request information are displayed on the display unit. 